Automatic subscriptions in publish-subscribe systems

In this paper, we describe how to automate the process of subscribing to complex publish-subscribe systems. We present a proof-of-concept prototype, in which we analyze Web browsing history to generate zero-click subscriptions to Web feeds and video news stories. Our experience so far indicates that user attention data is a promising source of data for automating the subscription process

TFHE-rs: A library for safe and secure remote computing using fully homomorphic encryption and trusted execution environments

Fully Homomorphic Encryption (FHE) and Trusted Execution Environ-ments (TEEs) are complementing approaches that can both secure computa-tions running remotely on a public cloud. Existing FHE schemes are, however, malleable by design and lack integrity protection, making them susceptible to integrity breaches where an adversary could modify the data and corrupt the output. This paper describes how both confidentiality and integrity of remote compu-tations can be assured by combining FHE with hardware based secure enclave technologies. We provide a software library for performing FHE within the Intel SGX TEE, written in the memory-safe programming language Rust to strengthen the internal safety of software and reduce its attack surface. We evaluate a sample application written with our library. We demonstrate that we can feasibly combine these concepts and provide stronger security guar-antees with a minimal development effort

Report on System Development, Method Applicability and Pipeline Condition Data for Modeling Purposes

Breivoll Inspection Technologies AS (BIT) is a Norwegian SME and a provider of condition assessment services to water utilities world-wide. BIT's role in the TRUST project is to provide data from inspections of water mains in participating cities to participating researchers. A pipeline condition database has previously been delivered in milestone MS31. This report evaluates the BIT method for condition assessment of water pipes. The inspection system, the client report and the pipeline condition database are presented, and the applicability of the BIT method is analyzed.Brenna, L.; Dyrkoren, PA.; Vangdal, AC.; Poulton, M.; Bruaset, S. (2014). Report on System Development, Method Applicability and Pipeline Condition Data for Modeling Purposes. http://hdl.handle.net/10251/3574

‘Not at all what I had expected’: Discontinuing treatment with extended-release naltrexone (XR-NTX): A qualitative study

Background: Extended-release naltrexone (XR-NTX), an opioid antagonist, has demonstrated equal treatment outcomes, in terms of safety, opioid use, and retention, to the recommended OMT medication buprenorphine. However, premature discontinuation of XR-NTX treatment is still common and poorly understood. Research on patient experiences of XR-NTX treatment is limited. We sought to explore participants' experiences with discontinuation of treatment with XR-NTX, particularly motivation for XR-NTX, experiences of initiation and treatment, and rationale for leaving treatment. Methods: We conducted qualitative, semi-structured interviews with participants from a clinical trial of XR-NTX. The study participants (N = 13) included seven women and six men with opioid dependence, who had received a minimum of one and maximum of four injections of XR-NTX. The study team analyzed transcribed interviews, employing thematic analysis with a critical realist approach. Findings: The research team identified three themes, and we present them as a chronological narrative: theme 1: Entering treatment – I thought I knew what I was going into; theme 2: Life with XR-NTX – I had something in me that I didn't want; and theme 3: Leaving treatment – I want to go somewhere in life. Patients' unfulfilled expectations of how XR-NTX would lead to a better life were central to decisions about discontinuation, including unexpected physical, emotional, or mental reactions as well as a lack of expected effects, notably some described an opioid effect from buprenorphine. A few participants ended treatment because they had reached their treatment goal, but most expressed disappointment about not achieving this goal. Some also expressed renewed acceptance of OMT. The participants' motivation for abstinence from illegal substances generally remained. Conclusion: Our findings emphasize that a dynamic understanding of discontinuation of treatment is necessary to achieve a long-term approach to recovery: the field should understand discontinuation as a feature of typical treatment trajectories, and discontinuation can be followed by re-initiation of treatment.‘Not at all what I had expected’: Discontinuing treatment with extended-release naltrexone (XR-NTX): A qualitative studypublishedVersionPaid open acces

Up-to-the-Minute Privacy Policies via Gossips in Participatory Epidemiological Studies

Researchers and researched populations are actively involved in participatory epidemiology. Such studies collect many details about an individual. Recent developments in statistical inferences can lead to sensitive information leaks from seemingly insensitive data about individuals. Typical safeguarding mechanisms are vetted by ethics committees; however, the attack models are constantly evolving. Newly discovered threats, change in applicable laws or an individual's perception can raise concerns that affect the study. Addressing these concerns is imperative to maintain trust with the researched population. We are implementing Lohpi: an infrastructure for building accountability in data processing for participatory epidemiology. We address the challenge of data-ownership by allowing institutions to host data on their managed servers while being part of Lohpi. We update data access policies using gossips. We present Lohpi as a novel architecture for research data processing and evaluate the dissemination, overhead, and fault-tolerance

Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3–90 years

Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce inconsistencies and may obscure or distort the lifespan trajectories of brain morphometry. In response, we capitalized on the resources of the Enhancing Neuroimaging Genetics through Meta‐Analysis (ENIGMA) Consortium to examine age‐related trajectories inferred from cross‐sectional measures of the ventricles, the basal ganglia (caudate, putamen, pallidum, and nucleus accumbens), the thalamus, hippocampus and amygdala using magnetic resonance imaging data obtained from 18,605 individuals aged 3–90 years. All subcortical structure volumes were at their maximum value early in life. The volume of the basal ganglia showed a monotonic negative association with age thereafter; there was no significant association between age and the volumes of the thalamus, amygdala and the hippocampus (with some degree of decline in thalamus) until the sixth decade of life after which they also showed a steep negative association with age. The lateral ventricles showed continuous enlargement throughout the lifespan. Age was positively associated with inter‐individual variability in the hippocampus and amygdala and the lateral ventricles. These results were robust to potential confounders and could be used to examine the functional significance of deviations from typical age‐related morphometric patterns

Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3-90 years

Delineating the association of age and cortical thickness in healthy individuals is critical given the association of cortical thickness with cognition and behavior. Previous research has shown that robust estimates of the association between age and brain morphometry require large‐scale studies. In response, we used cross‐sectional data from 17,075 individuals aged 3–90 years from the Enhancing Neuroimaging Genetics through Meta‐Analysis (ENIGMA) Consortium to infer age‐related changes in cortical thickness. We used fractional polynomial (FP) regression to quantify the association between age and cortical thickness, and we computed normalized growth centiles using the parametric Lambda, Mu, and Sigma method. Interindividual variability was estimated using meta‐analysis and one‐way analysis of variance. For most regions, their highest cortical thickness value was observed in childhood. Age and cortical thickness showed a negative association; the slope was steeper up to the third decade of life and more gradual thereafter; notable exceptions to this general pattern were entorhinal, temporopolar, and anterior cingulate cortices. Interindividual variability was largest in temporal and frontal regions across the lifespan. Age and its FP combinations explained up to 59% variance in cortical thickness. These results may form the basis of further investigation on normative deviation in cortical thickness and its significance for behavioral and cognitive outcomes

Engineering push-based web services

Much of the content of popular Internet information sources is highly dynamic: urgent in nature and sometimes relevant only for a short time. The typical approach to querying such dynamic sources is polling for updates often.1 This strains the traditional pull-based Internet and wastes network resources on transmitting redundant information. This paper focuses on how to structure the Internet to avoid the unnecessary client-server interactions dominating the Internet. To that end, we extend the API of popular existing Internet services trough Web service wrappers. These wrappers use the API of, for instance, Google, but provide functionality that is richer. Initial experience shows that major performance gains can be achieved through this approach

Configuring Push-Based Web Services

Much of the contents of popular Internet information sources is highly dynamic: urgent in nature and sometimes relevant only for a short time. The typical approach to querying such dynamic sources is polling for updates often. This strains the traditional pullbased Internet and wastes network resources on transmitting redundant information